AIC Genotyping Study

Sponsor
Barts & The London NHS Trust
Study ID
NCT07574697
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

To quantify genetic variants in a focused DCM gene panel among AF-induced cardiomyopathy (AIC) and positive/negative controls

Key Dates

Start date
Mar 25, 2026
Status verified
May 2026
Primary completion
Mar 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
299 participants (estimated)

Arms

  • Arm: AF induced Cardiomyopathy (Cases)
    Patients with LVSD during rate-controlled, persistent AF who improve their LVEF after sustained SR is achieved using catheter ablation or cardioversion.
  • Arm: AF-preserved EF (Negative controls)
    Patients without LVSD during rate-controlled, persistent AF
  • Arm: AF/HF non-responders (Positive controls)
    Patients with LVSD during rate-controlled, persistent AF who do not significantly improve their LVEF after sustained SR is achieved using catheter ablation or cardioversion.

Primary Outcome Measure

DCM gene prevalence relative to negative control [ Time Frame: On day of baseline testing (1 day) ]

Central Contacts

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