Effects of Adolescent Synaptic Pruning

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Beatriz Luna
Study ID
NCT07569718
Status
Enrolling By Invitation

Conditions

  • Healthy Adult Participants
  • Synaptic Plasticity

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • PET Imaging Scan using [11C]UCB-J — RADIATION
    \[11C\]UCB-J (\~ 15 mCi and ≤ 6μg) will be injected as a slow intravenous bolus. Following an intravenous bolus injection of \[11C\]UCB-J, the participants will be positioned in the scanner for a low dose CT scan (for attenuation correction) fifty-five minutes after the \[11C\]UCB-J injection, and emission data will be collected.

Study Details

The study will use a PET-based measure of brain cell (neuron) connections (synapses) in young adults who have also obtained an MRI, to assess how the loss of brain cell connections (synaptic pruning) is captured by MRI-based measures. This will inform youth MRI studies to understand neurotypical brain development that can help identify abnormal trajectories as in mental illness.

Key Dates

Start date
Jan 9, 2026
Status verified
May 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
60 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: PET Imaging Supplemental Component
    Adult participants enrolled in the parent study, will be given the option to be a part of the PET imaging supplemental project. Maximum enrollment is 60 adult participants. Interested participants will be consented into the PET portion, and will have a single PET scan (as outlined in the Study Description section).

Primary Outcome Measure

Non-invasive quantification of synaptic pruning [ Time Frame: The PET-CT scan will be within approximately 30 days of the parent study MRI. ]

Locations (1)

FacilityCityStateZIPSite coordinators
Laboratory of Neurocognitive DevelopmentPittsburghPennsylvania15213-

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Laboratory of Neurocognitive Development· Pittsburgh, PA

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