Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome

Part of paid clinical trials in Rochester, New York.

Sponsor
University of Rochester
Study ID
NCT07569445
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
2 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Electroencephalogram (EEG) Recording — PROCEDURE
    Participants will undergo a noninvasive electroencephalogram (EEG) recording to measure brain activity in response to auditory stimuli. During the procedure, participants will listen to simple sounds through headphones while brain signals are recorded. No behavioral responses are required.

Study Details

This observational research study is designed to learn more about how the brain processes sound in individuals with Rett syndrome. Participants will complete a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. In addition, parents or caregivers will complete questionnaires and an interview about the participant's symptoms, communication abilities, daily functioning and overall health. The information collected from this study may help researchers better understand brain activity patterns and clinical features associated with Rett syndrome and support future research efforts.

Key Dates

Start date
Jul 31, 2025
Status verified
Apr 2026
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: Rett Syndrome Participants
    Individuals with Rett syndrome who participate in this observational study will undergo a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. Parents or caregivers will complete questionnaires and interviews related to the participant's symptoms, communication abilities, daily functioning and overall health. A Rett syndrome severity scale may also be completed by a clinician or trained member of the research team.
  • Arm: Age- and sex-matched controls
    Individuals who are age- and sex-matched to Rett syndrome participants in this study will be enrolled as controls. Control participants must have no medical history of genetic, neurological, or psychiatric disorders, no history of special education services, and no hearing impairment. Control participants in this study will undergo a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. Control participants (or their parent) will also complete a demographics questionnaire.

Primary Outcome Measure

Mean Auditory Evoked Response Amplitude Measured by EEG [ Time Frame: Assessed at a single study visit (baseline, up to 1 day) ]

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical CenterRochesterNew York14620
Jamison Seabury, BS
[email protected]
315-663-4159

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By research site
Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center· Rochester, NY

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