Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance

Conditions

• Knee Arthritis Osteoarthritis

Eligibility Criteria

Sex

ALL

Age

50 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Triamcinolone knee injection without ultrasound guidance — DRUG
  3mL lidocaine (without epinephrine) 1% solution combined with 1mL triamcinolone acetonide injectable solution, USP (40mg per mL)
• Triamcinolone knee injection with ultrasound guidance — COMBINATION_PRODUCT
  3mL lidocaine (without epinephrine) 1% solution combined with 0.5mL triamcinolone acetonide injectable solution, USP (40mg per mL)

Study Details

The purpose of this study is to determine whether a lower dose of corticosteroid injection with ultrasound-guidance for the treatment of knee osteoarthritis can be as effective as a higher dose that is landmark-guided. With landmark-guided dosing, it may be reasonable to use a higher amount of corticosteroid in order to ensure a sufficient amount of the medication is administered, however these injections carry the risk of side effects. Alternatively, with the use of ultrasound, it may be reasonable to use less corticosteroid, possibly decreasing the risk of side effects and increasing patient satisfaction.

Key Dates

Start date

Dec 12, 2025

Status verified

Apr 2026

Primary completion

Dec 8, 2026

Completion

Dec 8, 2026

Study Design

Enrollment

140 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: 40mg landmark-guided triamcinolone knee joint injection
• Experimental: 20mg ultrasound-guided triamcinolone knee injection

Primary Outcome Measure

Western Ontario and McMaster Universities Index [ Time Frame: From enrollment to 3 months ]

Locations (4)

Find similar trials in Ventura, CA