Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne.

Conditions

• Acne Vulgaris

Eligibility Criteria

Sex

ALL

Age

9 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Sarecycline — DRUG
  One tablet by mouth (weight based dosing at 1.5 mg/kg and rounded to the closest tablet dose at either 60 mg, 100mg, or 150 mg tablet) once a day with food and a full glass of water (about 8 ounces)
• Doxycycline — DRUG
  100 mg twice daily with food and a full glass of water (about 8 ounces)

Study Details

This study is being done to help better understand how the gut and skin bacteria of the body change when people with acne are treated with Sarecycline or Doxycycline. The bacteria in the gut and on the skin will be studied to see how each treatment may affect them and whether they change the profile of the bacteria that is present.

Key Dates

Start date

Apr 20, 2026

Status verified

Apr 2026

Primary completion

Apr 30, 2027

Completion

Jun 30, 2027

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Sarecycline Group
  Half of the participants will be randomized to receive sarecycline treatment.
• Experimental: Doxycycline Group
  Half of the participants will be randomized to receive doxycycline treatment.

Primary Outcome Measure

Change in the relative abundance of tetracycline-resistant bacteria in the gut microbiome [ Time Frame: From enrollment to the end of treatment at 4 weeks. ]

Central Contacts

• Nasima Afzal Chief Operating Officer
  916-775-5080
  [email protected]

Locations (1)

Find similar trials in Sacramento, CA

Related Studies

• Weekly Isotretinoin vs Tetracycline for Moderate Acne
  EARLY_PHASE1 · Recruiting · Medical University of South Carolina · Charleston, South Carolina