A Web-Based Program (Kindred) to Improve the Understanding of Genetic Cancer Risk and Cancer Genetic Testing in African American Families

Conditions

• BRCA1-Related Hereditary Breast and Ovarian Cancer Syndrome
• BRCA2-Related Hereditary Breast and Ovarian Cancer Syndrome
• Hereditary Neoplastic Syndrome
• Lynch Syndrome

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Discussion — OTHER
  Ancillary studies
• Internet-Based Intervention — OTHER
  Receive access to the Kindred web-based portal
• Internet-Based Intervention — OTHER
  Share information and invite relatives
• Survey Administration — OTHER
  Ancillary studies
• Telephone-Based Intervention — BEHAVIORAL
  Receive check-in calls

Study Details

This clinical trial studies whether a web-based program, Kindred, works to improve the understanding of genetic cancer risk and cancer genetic testing in African American families. Between 5% and 10% of all cancers are caused by genetic changes that are hereditary, which means that they run in families. Some kinds of cancer or a family history of cancer means individuals are more likely to have a genetic change. If a genetic change is identified in a family, other relatives can choose to undergo hereditary cancer genetic testing to better understand their cancer risk. In families where a genetic change is not identified, or results are uncertain, relatives may also benefit from discussing their cancer risk with providers and, in some cases, getting hereditary cancer genetic testing themselves. Research has shown that African Americans are less likely than other racial groups to engage in cancer genetic testing. Kindred is an online tool that provides information so individuals can learn about their cancer genetic test results, how cancer genetic testing can help individuals and families understand their overall cancer risk (and strategies for reducing risk), and ways to talk with each other about cancer risk and health. This may be an effective way to improve the understanding of genetic cancer risk and cancer genetic testing in African American families.

Key Dates

Start date

Jun 15, 2026

Status verified

May 2026

Primary completion

Jun 30, 2028

Completion

Jun 30, 2028

Study Design

Enrollment

150 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

SEQUENTIAL

Primary purpose

HEALTH_SERVICES_RESEARCH

Arms

• Experimental: Probands (Kindred, invite relatives)
  Probands receive access to the Kindred web-based portal on study consisting of the following sections: Share and Invite, Meaning of Results, Implications of Results, Communication with Family, Dissemination Plan, Looking Ahead, Glossary, FAQ, Resources List, and Public-Facing Website Information. Probands may optionally share information about their test results and invite \>= 4 relatives to join the study via the Share and Invite section in the Kindred portal. Probands also receive two check-in calls at 2- and 4- weeks post-baseline.
• Experimental: Relatives (Kindred)
  Invited relatives receive access to the Kindred web-based portal on study consisting of the following sections: Meaning of Results, Implications of Results, Communication with Family, Getting Testing, Looking Ahead, Glossary, FAQ, Resources List, and Public-Facing Website Information.

Primary Outcome Measure

Recruitment rates (Feasibility) [ Time Frame: Up to 2 years ]

Central Contacts

• Cacner AnswerLine
  1-800-865-1125
  [email protected]

Locations (1)

Find similar trials in Ann Arbor, MI

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