Predictors & Mechanisms of Adolescent PTSD

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07537764
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Posttraumatic Stress Disorder (PTSD)
  • Trauma Exposure

Eligibility Criteria

Sex
ALL
Age
14 Years - 18 Years
Healthy Volunteers
Not accepted

Interventions

  • Repeated imaginal exposure: Script Driven Imagery (SDI) task — BEHAVIORAL
    Repeated administration (5 repetitions) of a script including details of the individual's exposure to a traumatic event.

Study Details

This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to potential threats, regulating emotions, and repeatedly imagining details of a personally experienced stressful or traumatic event using a script-driven imagery task. The study evaluates whether repeated imaginal exposure is associated with changes in anxiety and physiological responses across sessions, and whether baseline patterns of threat reactivity and emotion regulation are associated with individual differences in response to the exposure task. Outcomes include self-reported anxiety, subjective distress ratings, and psychophysiological indices such as heart rate, skin conductance, and electromyographic activity. The goal of this research is to improve understanding of biobehavioral processes related to trauma exposure in adolescents and to identify potential predictors of response to exposure-based intervention components relevant to posttraumatic stress disorder (PTSD).

Key Dates

Start date
Sep 30, 2026
Status verified
May 2026
Primary completion
Mar 31, 2031
Completion
Mar 31, 2031

Study Design

Enrollment
180 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Exposure Arm

Primary Outcome Measure

State Anxiety (State and Trait Anxiety Inventory for Children - State Scale) [ Time Frame: Baseline (Visit 1, prior to first script-driven imagery task) and 1 week after baseline (Visit 2, following repeated imaginal exposure) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29425
Rachel Siciliano, Ph.D.
[email protected]
8437923629
Carla Kmett Danielson, Ph.D.
[email protected]
843-792-3599
Rachel Siciliano, Ph.D. (PRINCIPAL_INVESTIGATOR)

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