Comparing Prebiotic Fiber Supplements for Gut Health and Digestive Comfort

Part of paid clinical trials in San Francisco, California.

Sponsor
Ventoscity LLC
Study ID
NCT07525180
Status
Not Yet Recruiting

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Conditions

  • Healthy Participants

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • LOAM — DIETARY_SUPPLEMENT
    12 grams of LOAM daily
  • Inulin — DIETARY_SUPPLEMENT
    12 Grams Inulin daily
  • Cellulose Placebo — DIETARY_SUPPLEMENT
    12 grams of cellulose placebo daily

Study Details

This study compares three dietary fiber supplements - LOAM prebiotic fiber, inulin, and a cellulose placebo - to evaluate their effects on intestinal gas production and gastrointestinal comfort in healthy adults who currently eat a low-fiber diet. Participants will be randomly assigned to one of the three supplements and asked to take one daily serving mixed with water for four weeks. Intestinal gas production will be measured using Ventos, a wearable device that continuously monitors intestinal gas when worn near the body. Participants wear the device for approximately 22 hours on two designated days per week throughout the 5-week study. Gastrointestinal symptoms including bloating, abdominal discomfort, and stool consistency will be tracked daily using a symptom diary and standardized questionnaires. The study is conducted entirely remotely. Participants receive their supplement and the Ventos device by mail and complete all study activities from home using a smartphone or computer. The study runs for five weeks, including one baseline week before supplementation begins. The goal is to determine whether LOAM prebiotic fiber causes less intestinal gas and better gastrointestinal tolerability during the initial weeks of supplementation compared to inulin, while also validating the Ventos device as a research measurement tool in a controlled supplement study.

Key Dates

Start date
Apr 15, 2026
Status verified
Apr 2026
Primary completion
Aug 1, 2026
Completion
Aug 1, 2026

Study Design

Enrollment
125 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: LOAM
    12 grams LOAM prebiotic daily
  • Active Comparator: Inulin
    12 grams inulin daily
  • Placebo Comparator: Cellulose Placebo
    12 grams cellulose daily

Primary Outcome Measure

Change in Average Daily Flatus from Baseline (Week 1) to Week 2, Comparing LOAM Prebiotic Fiber to Inulin [ Time Frame: Baseline (Week 1) to Week 2 (first week of supplementation) ]

Locations (1)

FacilityCityStateZIPSite coordinators
AlethiosSan FranciscoCalifornia94109
Zeenia Framroze
(650) 206-8006

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By research site
Alethios· San Francisco, CA

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