Wearable Photoplethysmography for Non-invasive Hydration Assessment

Conditions

• Hydration Status

Eligibility Criteria

Sex

ALL

Age

18 Years - 45 Years

Healthy Volunteers

Accepted

Interventions

• Exercise — OTHER
  Perform stationary cycling exercise in the laboratory for 2 30- minute bouts at a standardized exercise intensity (wattage) that elicits 50-80% heart rate max determined by equation (208-(70% of age))

Study Details

Hydration status during exercise is often determined by measuring body mass change, fluid intake and urine output. However, obtaining these measurements can be an invasive, time-consuming process. Hydration status may be detectable by analyzing blood flow patterns of the superficial (just under the skin) blood vessels. Wearable devices are now abundant among the general population, and despite attempts from several groups, a hydration status metric based on noninvasive wearable device metrics has not been developed. With wearables, a light source connected to an optical sensor transmits and reflects light through the body. The light sensor detects absorption of the light based on wavelength measurements of the detected light. Absorption of specific wavelengths of light energy is dependent upon the amount of oxygenated blood in the vessels. When the vessels expand and relax, the amount of blood volume in the observed tissue increases and decreases potentially causing a shift in the photoplethysmography (PPG) wave detected by the wearable. The shift in the shape of the PPG wave may be detected in a way that indicates the relative change in tissue hydration levels. However, to our knowledge, no wrist worn device that utilizes PPG has been successfully able to predict hydration status. Therefore, this study aims to utilize photoplethysmography (PPG) technology in a wearable device to accomplish this approach to hydration monitoring.

Key Dates

Start date

Apr 1, 2026

Status verified

Apr 2026

Primary completion

Sep 30, 2026

Completion

Oct 31, 2026

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Arms

• Other: Euhydrated Group
  Water provided to account for sweat loss during exercise and to maintain hydration over the 24-hour period
• Experimental: Dehydrated Group
  Fluid restriction during exercise and the remaining 24 hours

Primary Outcome Measure

Wearable Sensr Data [ Time Frame: Continuous data collection over 24 hours from start of exercise trial through completion of Day 2 measurements. ]

Central Contacts

• Anthony Wolfe
  574-315-5901
  [email protected]

Locations (2)

Find similar trials in Frisco, TX

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