C-3002: Enhancing Cervical Cancer Screening Access and Follow-up Care at 'CASCADE' Clinical Sites in the United States

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
UNC Lineberger Comprehensive Cancer Center
Study ID
NCT07520188
Status
Not Yet Recruiting

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Conditions

  • Cervical Cancer
  • Cervical Precancer
  • Human Immunodeficiency Virus (HIV)
  • Human Papillomavirus (HPV)

Eligibility Criteria

Sex
ALL
Age
25 Years - 49 Years
Healthy Volunteers
Accepted

Interventions

  • Qualitative interviews — BEHAVIORAL
    In-depth qualitative interviews will be conducted with women with Human Immunodeficiency Virus (HIV) receiving care to explore barriers and facilitators to cervical cancer screening and follow-up care.
  • Focus groups — BEHAVIORAL
    Focus groups will be conducted with multidisciplinary care team members to assess perceived clinical workflow challenges, access barriers, and health system constraints related to current cervical cancer screening and follow-up protocols.

Study Details

The purpose of the CASCADE-3002 project is to improve access to cervical cancer screening among women with Human Immunodeficiency Virus (HIV) receiving care at U.S.-based CASCADE clinical sites. This study will assess the cervical cancer screening cascade and identify multilevel factors that impede access to screening among women with HIV attending Infectious Disease clinics in Georgia and Maryland. In parallel, the study will explore and develop implementation strategies for human papillomavirus (HPV) self-collection to increase screening uptake, adherence, and appropriate clinical follow-up in this population at elevated risk for cervical cancer. Cervical cancer remains a preventable malignancy; however, women with HIV are at substantially increased risk and experience higher rates of cervical cancer compared with women without HIV. The World Health Organization has called for the global elimination of cervical cancer as a public health problem, defined as fewer than 4 incident cases per 100,000 women annually, with targets for vaccination, screening, and treatment coverage. Although the United States has the tools to approach near-elimination, disparities in healthcare access and screening persist, particularly among women with HIV.

Key Dates

Start date
Jun 30, 2026
Status verified
Jun 2026
Primary completion
Feb 28, 2027
Completion
May 31, 2027

Study Design

Enrollment
3,500 participants (estimated)

Arms

  • Arm: Women with Human Immunodeficiency Virus (HIV)
    Women with Human Immunodeficiency Virus (HIV) are eligible for cervical cancer screening and/or receiving care.
  • Arm: Healthcare providers
    Healthcare providers (e.g. physicians, nurse practitioners, physician's assistants, nurses, nursing assistants, medical assistants, pharmacists), laboratory members, and IT Specialist/Medical Records Experts providing care to WWH.

Primary Outcome Measure

Barriers and facilitators to cervical cancer screening and follow-up among women with HIV [ Time Frame: Baseline ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Emory University SOM Division/Department: Gynecology & ObstetricsAtlantaGeorgia30303
Lisa Flowers, MD, MPH
[email protected]
404-251-8931
Lisa Flowers, MD, MPH (PRINCIPAL_INVESTIGATOR)
Anandi Sheth, MD, MSc (PRINCIPAL_INVESTIGATOR)
University of Maryland School of Medicine Division of Family and Community MedicineBaltimoreMaryland21201
Gregory Taylor, MD
[email protected]
410-225-8369
Gregory Taylor, MD (PRINCIPAL_INVESTIGATOR)
Clement Adebamowo, ScD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Atlanta, GA

By condition
Cervical cancer
By specialty
OncologyGynecologic oncologyWomen's health
By research site
Emory University SOM Division/Department: Gynecology & Obstetrics· Atlanta, GAUniversity of Maryland School of Medicine Division of Family and Community Medicine· Baltimore, MD

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