Mapping LIFU Responses Using iEEG Recordings

Conditions

• Electrodes, Implanted
• Low Intensity Focussed Ultrasound

Eligibility Criteria

Sex

ALL

Age

21 Years - 75 Years

Healthy Volunteers

Not accepted

Interventions

• Low Intensity Focused Ultrasound — DEVICE
  The study visit consists of non-therapeutic transcranial low-intensity focused ultrasound pulses given while patient has intracranial electrodes implanted.

Study Details

The current study presents a unique opportunity to measure the immediate neural responses to brief, non-therapeutic transcranial low-intensity focused ultrasound (LIFU) pulses using intracranial electrodes. By recording time-locked signals in local and distant brain regions we can characterize circuit connectivity in real-time. We will use adult patients undergoing intracranial electrophysiological monitoring in an inpatient setting as our targeted population.

Key Dates

Start date

Mar 4, 2026

Status verified

Apr 2026

Primary completion

Mar 4, 2031

Completion

Mar 4, 2031

Study Design

Enrollment

30 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: LIFU Experiment

Primary Outcome Measure

Local spectral responses and temporally linked network activity, as measured by intracranial EEG [ Time Frame: From enrollment to end of study is two weeks ]

Locations (1)

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