Vitamin K for Perioperative Warfarin Management

Conditions

• Anticoagulant Therapy

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Vitamin K — DRUG
  10 mg of oral vitamin K will be given approximately 36-48 hours before procedure.
• Warfarin (standard without loading) — DRUG
  Patients receive their standard warfarin dosing without interruption.
• Warfarin (standard with loading) — DRUG
  Patients receive their standard warfarin dosing without interruption; patients also receive a one time loading dose (twice normal dose) of warfarin on the evening following their procedure.

Study Details

This is a feasibility study of uninterrupted warfarin with a one time dose of Vitamin K before a surgical procedure.

Key Dates

Start date

Jul 3, 2025

Status verified

Apr 2026

Primary completion

Aug 31, 2026

Completion

Aug 31, 2026

Study Design

Enrollment

20 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Standard Warfarin Dosing with Vitamin K
  Patients will receive their standard warfarin dosing before, during, and after their procedure. This is in addition to a one time dose of oral vitamin K pre-procedure.
• Experimental: Loading Warfarin Dosing with Vitamin K
  Patients will receive their standard warfarin dosing before and during their procedure. On the night following the procedure, they will receive a one time loading dose of warfarin (twice their normal dose). Patients will then resume normal dosing of warfarin. This is in addition to a one time dose of oral vitamin K pre-procedure.

Primary Outcome Measure

Feasibility of patient recruitment [ Time Frame: Within two weeks (from outreach to five days prior to procedure) ]

Central Contacts

• Geoffrey Barnes, MD
  734 936-4000
  [email protected]

Locations (1)

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