Examining Olive Oil Extract on Knee Comfort and Function

Part of paid clinical trials in San Francisco, California.

Sponsor
Applied Food Sciences Inc.
Study ID
NCT07514013
Status
Recruiting
Apply to this trial

Conditions

  • Healthy Adult Females
  • Healthy Adult Male
  • Joint Discomfort

Eligibility Criteria

Sex
ALL
Age
40 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Olive Oil Extract — DIETARY_SUPPLEMENT
    The investigational product is an olive oil extract dietary supplement formulated for oral consumption. The product is provided in capsule form and is intended for general wellness use, including support of joint comfort and function. Each capsule delivers a standardized amount of olive-derived bioactive compounds, including oleocanthal and oleacein.
  • Placebo — DIETARY_SUPPLEMENT
    The comparator product is a matched placebo formulated from refined olive oil extract and is similar in appearance, taste, and packaging to the investigational product. The placebo is intended to serve as a control for study comparisons and does not contain the standardized olive-derived bioactive compounds present in the investigational product.

Study Details

The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and discomfort, and 2) Does the olive oil extract improve knee function in adults? The main procedures in the study include: * Screening and informed consent * Take one assigned study capsule (supplement or placebo) daily with food for 6 weeks * Complete digital questionnaires about your knee pain, stiffness, and function at scheduled times * Complete a Day 1 acute assessment and two simple functional movement tests at home as described below * If possible, connect a compatible wearable device to allow collection of sleep and physical activity data as detailed below. * Collect saliva samples at home using a provided kit at designated timepoints * Record any pain medications taken during the study or any side effects

Key Dates

Start date
Apr 30, 2026
Status verified
Apr 2026
Primary completion
Oct 1, 2026
Completion
Nov 1, 2026

Study Design

Enrollment
168 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Placebo
    Participants randomized to this arm will receive a matched placebo capsule taken once daily with food for 6 weeks. The placebo is formulated to be similar in appearance, taste, and packaging to the investigational product but does not contain the active olive-derived bioactive compounds
  • Experimental: Olive Oil Extract
    Participants randomized to this arm will receive an olive oil extract dietary supplement capsule taken once daily with food for 6 weeks. The supplement delivers olive-derived bioactive compounds (including oleocanthal and oleacein) and is intended for general wellness use related to joint comfort and function.

Primary Outcome Measure

Change in Knee pain (KOOS Pain subscale) [ Time Frame: After 0, 1, 2, 3, 4, 5, and 6 weeks of supplementation. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Alethios, Inc.San FranciscoCalifornia94104
Zeenia Framroze, MS
[email protected]
650-208-8006
Zoe Benham, BS
[email protected]
650-208-8006

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By research site
Alethios, Inc.· San Francisco, CA

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