Study of Efficacy and Safety of Tonlamarsen in Participants With Acute Severe Hypertension Recently Discharged From the Hospital

Part of paid clinical trials in Arvada, Colorado.

Sponsor
Kardigan, Inc.
Study ID
NCT07511361
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Tonlamarsen — DRUG
    Tonlamarsen will be administered subcutaneously (under the skin) every 4 weeks during the randomized part of the study
  • Placebo — DRUG
    Placebo will be administered subcutaneously (under the skin) every 4 weeks during the randomized part of the study

Study Details

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently discharged from the hospital, after treatment for acute severe hypertension.

Key Dates

Start date
Apr 20, 2026
Status verified
May 2026
Primary completion
Dec 29, 2026
Completion
Feb 23, 2027

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Tonlamarsen
    3 doses active drug will be administered by subcutaneous (under the skin) injection (one dose every 4 weeks)
  • Placebo Comparator: Placebo
    3 doses of placebo will be administered by subcutaneous (under the skin) injection (one dose every 4 weeks)

Primary Outcome Measure

To assess the effect of tonlamarsen on plasma angiotensinogen (AGT) levels [ Time Frame: Week 12 ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
Western Nephrology and Metabolic Bone Disease, PC - ArvadaArvadaColorado80002
Kardigan Clinical Study Information Team
[email protected]
877-310-5135
Homestead Associates in ResearchHomesteadFlorida33033
Kardigan Clinical Study Information Team
[email protected]
877-310-5135
Progressive Medical ResearchPort OrangeFlorida32127
Kardigan Clinical Study Information Team
[email protected]
877-310-5135
Chattanooga Research & Medicine CHARMChattanoogaTennessee37404
Kardigan Clinical Study Information Team
[email protected]
877-310-5135

Find similar trials in Arvada, CO

By condition
Hypertension (high blood pressure)
By specialty
CardiologyHeart disease
By research site
Western Nephrology and Metabolic Bone Disease, PC - Arvada· Arvada, COHomestead Associates in Research· Homestead, FLProgressive Medical Research· Port Orange, FLChattanooga Research & Medicine CHARM· Chattanooga, TN

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