Membrane Potential Mapping with18F-TPP

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT07506616
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

  • Membrane Potential Mapping

Eligibility Criteria

Sex
ALL
Age
21 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • 18F-TPP — DRUG
    radiotracer specific for imaging mitochondrial membrane potential (ΔΨm) administered intravenously

Study Details

In this study, investigators propose to use PET imaging to study the pharmacokinetics of 18F-TPP and develop methods for imaging membrane potential (ΔΨT) in humans.

Key Dates

Start date
Jun 30, 2026
Status verified
Sep 2025
Primary completion
Aug 31, 2033
Completion
Aug 31, 2033

Study Design

Enrollment
24 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: 18F-TPP
    PET imaging to study the pharmacokinetics of 18F-TPP and develop methods for imaging membrane potential (ΔΨT) in humans. Each scan may or may not have arterial blood sampling for measurement of the time course of radioactivity in the whole-blood, plasma and radiometabolite analysis on selected plasma samples.

Primary Outcome Measure

Tracers volume of distribution (VT) [ Time Frame: Visit 2 (up to 90 days post screening visit 1) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Yale University PET CenterNew HavenConnecticut06510-

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By research site
Yale University PET Center· New Haven, CT