Understanding the Long-term Impact of COVID-19 in Adults

Part of paid clinical trials in New York, New York.

Sponsor
NYU Langone Health
Study ID
NCT07498504
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Not accepted

Study Details

Long COVID (LC) affects an estimated 5-10% of individuals with SARS-CoV-2 causing a persistent physical, cognitive, and functional impairment with potentially severe socioeconomic consequences. While RECOVER-Adult cycle 1 established the largest, most comprehensive U.S. adult LC cohort (14,730 participants), key questions remain about long-term disease trajectories, biological mechanisms, and late-emerging complications. RECOVER-Adult cycle 2 will follow selected participants for two years each, focusing on neurocognitive, cardiopulmonary and infection-associated chronic conditions (IACC) such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and autonomic dysfunction. Using a case-cohort design, the study will investigate disease persistence versus resolution, biological mechanisms, and onset of new chronic illnesses, generating critical insights to guide prevention, treatment, and public health policy.

Key Dates

Start date
May 31, 2026
Status verified
Mar 2026
Primary completion
Apr 30, 2030
Completion
Apr 30, 2030

Study Design

Enrollment
5,205 participants (estimated)

Arms

  • Arm: Case Group
    Individuals who met LC enrichment criteria in RECOVER-Adult cycle 1.
  • Arm: Control Group
    Individuals who did not meet LC enrichment criteria in RECOVER-Adult cycle 1.

Primary Outcome Measure

Percentage of Long COVID Research Index (LCRI) Score of 11 or Higher [ Time Frame: Baseline, Month 6, Month 12, Month 18, Month 24 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
NYU Langone HealthNew YorkNew York10016-

Find similar trials in New York, NY

By condition
COVID-19 / long COVID
By specialty
Infectious disease
By research site
NYU Langone Health· New York, NY

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