The Acute Effects of Onnit Alpha Brain on Cognition and Mood States

Part of paid clinical trials in Tampa, Florida.

Sponsor
Applied Science & Performance Institute
Study ID
NCT07495592
Status
Not Yet Recruiting

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Conditions

  • Cognitive
  • Executive Function (Cognition)
  • Fatigue
  • Mood and Cognitive Performance
  • Sleep Deprivation

Eligibility Criteria

Sex
ALL
Age
20 Years - 59 Years
Healthy Volunteers
Accepted

Interventions

  • Alpha Brain proprietary cognitive dietary supplement — DIETARY_SUPPLEMENT
    Alpha Brain is a proprietary investigational dietary supplement. The formulation contains a combination of dietary ingredients commonly used in cognitive supplement mixes.
  • Alpha Brain 2.0 proprietary cognitive dietary supplement — DIETARY_SUPPLEMENT
    Alpha Brain 2.0 is a proprietary investigational dietary supplement. The formulation contains a combination of dietary ingredients commonly used in cognitive supplements and will be evaluated under double-blind conditions in a randomized, placebo-controlled crossover study.
  • Controlled Placebo — DIETARY_SUPPLEMENT
    The placebo consists of an inactive placebo mix administered orally as two capsules.

Study Details

The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive performance, vigilance, and subjective mood in healthy adults compared to placebo during a period of acute sleep deprivation under conditions of controlled sleep deprivation.

Key Dates

Start date
Apr 16, 2026
Status verified
Mar 2026
Primary completion
Aug 1, 2026
Completion
Aug 15, 2026

Study Design

Enrollment
34 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Alpha Brain
    Alpha Brain investigational dietary supplement administered as two oral capsules with water
  • Active Comparator: Alpha Brain 2.0
    Alpha Brain 2.0 investigational dietary supplement administered as two oral capsules with water
  • Placebo Comparator: Control Treatment
    Inactive/inert placebo capsules administered as two oral capsules with water

Primary Outcome Measure

Psychomotor Vigilance Test [ Time Frame: Subjects will complete this on each of the three visits at baseline, and then repeated at 60 minutes, 120 minutes, and 180 minutes post supplementation. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Applied Science Performance InstituteTampaFlorida33634
Eric Sikorski, PhD
[email protected]
8138678888
Gabe Wilson, PhD
[email protected]
8138678888

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Applied Science Performance Institute· Tampa, FL

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