Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants With Solid and Hematologic Cancers

Part of paid clinical trials in Hialeah, Florida.

Sponsor
Regeneron Pharmaceuticals
Study ID
NCT07493304
Phase
PHASE3
Status
Recruiting
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Conditions

  • Venous Thromboembolism (VTE)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • REGN7508 — DRUG
    Administered per the protocol
  • Apixaban — DRUG
    Administered per the protocol

Study Details

This study is researching an experimental drug called REGN7508 (called "study drug") and will consist of 2 parts: Part 1 and Part 2. The study is focused on participants with or without cancer who develop blood clots in certain veins (called Deep Vein Thrombosis \[DVT\]) that block blood flow (Part 1) or focused on participants with cancer who develop blood clots in certain veins (DVT) or the lungs (also called Pulmonary Embolism \[PE\]) (Part 2). The aim of the study is to see how safe and effective the study drug is at treating and preventing further blood clots in participants with or without cancer (Part 1) or in participants with cancer (Part 2) compared with another treatment (apixaban). The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)

Key Dates

Start date
Jun 30, 2026
Status verified
May 2026
Primary completion
Jul 8, 2031
Completion
Jul 8, 2031

Study Design

Enrollment
1,600 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: REGN7508
  • Active Comparator: Apixaban

Primary Outcome Measure

Occurrence of Treatment-Emergent Adverse Events (TEAEs) [ Time Frame: Approximately 6 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Bioresearch Partner- Hialeah HospitalHialeahFlorida33013-
El Paso Medical Research Institute (Medresearch Inc)El PasoTexas79902-

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Bioresearch Partner- Hialeah Hospital· Hialeah, FLEl Paso Medical Research Institute (Medresearch Inc)· El Paso, TX

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