A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Lobular Breast Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07483307
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Breast Cancer
  • ER+ Breast Cancer
  • HER2 Negative Breast Carcinoma
  • HER2-negative Breast Cancer
  • Lobular Breast Carcinoma

Eligibility Criteria

Sex
FEMALE
Age
50 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Neoadjuvant endocrine therapy — DRUG
    The endocrine therapy used for the NET in this study will be anastrozole, letrozole, exemestane, or tamoxifen.

Study Details

The purpose of this study is to look at how effective neoadjuvant (before surgery) endocrine therapy (NET) is in participants with invasive lobular carcinoma (ILC) who have breast-conserving surgery (BCS). The main purpose of the study is to see if NET reduces the chance of having cancer cells at the edges of tissue removed during surgery (positive margins).

Key Dates

Start date
Mar 13, 2026
Status verified
Jun 2026
Primary completion
Mar 13, 2030
Completion
Mar 13, 2030

Study Design

Enrollment
176 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with ER+/HER2- Breast Cancer
    Participants will be postmenopausal women aged ≥50 years with biopsy-proven cT2-T3 N0-1 ILC, ER+/HER2- subtype

Primary Outcome Measure

Rate of positive surgical margins after breast cancer surgery [ Time Frame: up to 3 months ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Anita Mamtani, MD
646-888-6864
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)MiddletownNew Jersey07748
Anita Mamtani, MD
646-888-6864
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Anita Mamtani, MD
646-888-6864
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)CommackNew York11725
Anita Mamtani, MD
646-888-6864
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Anita Mamtani, MD
646-888-6864
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Anita Mamtani, MD
646-888-6864
Memorial Sloan Kettering Nassau (Limited Protocol Activities)UniondaleNew York11553
Anita Mamtani, MD
646-888-6864

Find similar trials in Basking Ridge, NJ

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

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