Systemic Inflammation, Thyroid Autoimmunity and Neuroretinal Changes in Graves Disease

Sponsor
Elazıg Fethi Sekin Sehir Hastanesi
Study ID
NCT07480720
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

This retrospective observational study aims to evaluate the relationship between systemic inflammatory parameters, thyroid autoimmunity markers, and neuroretinal structures in patients with Graves disease. Medical records of patients diagnosed with Graves disease and healthy control subjects evaluated at Elazığ Fethi Sekin City Hospital between August 2018 and January 2026 will be reviewed. Optical coherence tomography (OCT) measurements, including macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, will be analyzed. Laboratory parameters such as complete blood count-derived inflammatory indices, C-reactive protein, thyroid function tests, and thyroid autoantibodies will also be recorded. The study will compare neuroretinal parameters between healthy controls, Graves disease patients without ophthalmopathy, and Graves disease patients with ophthalmopathy, and will investigate potential associations between systemic inflammation, thyroid autoimmunity, and neuroretinal structural changes.

Key Dates

Start date
Mar 1, 2026
Status verified
Mar 2026
Primary completion
Apr 1, 2026
Completion
May 1, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Healthy Controls
    Age-matched healthy individuals without known thyroid disease or autoimmune disorders who underwent ophthalmologic examination and optical coherence tomography evaluation.
  • Arm: Graves Disease Without Ophthalmopathy
    Patients diagnosed with Graves disease who do not have clinical signs of Graves ophthalmopathy and who underwent optical coherence tomography evaluation.
  • Arm: Graves Disease With Ophthalmopathy
    Patients diagnosed with Graves disease who have clinical findings consistent with Graves ophthalmopathy and who underwent optical coherence tomography evaluation.

Primary Outcome Measure

Peripapillary Retinal Nerve Fiber Layer Thickness [ Time Frame: Retrospective evaluation of OCT measurements obtained between August 2018 and January 2026 ]

Central Contacts

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