Radiofrequency Ablation For Recurrent Parathyroid Carcinoma

Conditions

• Recurrent Parathyroid Carcinoma

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Ultrasound-guided RFA — DEVICE
  Participants will be positioned supine with full neck extension. Preprocedural intraoperative PTH will be drawn. Radiofrequency ablation (RFA) will be performed on one or up to 5 nodules on ipsilateral side per participant.

Study Details

The study will be an effectiveness study. The study will include enrollment of a total of 20 patients with at least one PC lesion for ultrasound guided RFA to PC recurrence in the neck to assess the effectiveness in reducing patient's hypercalcemia. Patients will have surgically proven PC from prior parathyroidectomy and suspicious PC visible on ultrasound and request for treatment for uncontrolled hypercalcemia (Figure 1).

Key Dates

Start date

Apr 9, 2026

Status verified

Apr 2026

Primary completion

Apr 30, 2029

Completion

Apr 30, 2031

Study Design

Enrollment

20 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Arms

• Experimental: Treatment with Ultrasound-guide RFA
  Participants treatment will be administered on an outpatient basis.

Primary Outcome Measure

Safety and Adverse Events (AEs) [ Time Frame: Through study completion; an average of 1 year ]

Central Contacts

• Thinh Vu, MD
  (281) 415-2061
  [email protected]

Locations (1)

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