Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat

Part of paid clinical trials in Cedar Falls, Iowa.

Sponsor
University of Northern Iowa
Study ID
NCT07472426
Status
Recruiting
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Conditions

  • Acute Kidney Injury
  • Exertional Heat Illness

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Creatine Monohydrate — DIETARY_SUPPLEMENT
    20 grams per day of creatine monohydrate for 7 days, followed by 1 day of 5 grams of supplementation.
  • Maltodextrin (Placebo) — DIETARY_SUPPLEMENT
    Participants will ingest 20 grams per day for 7 days, followed by 1 day of 5 grams.

Study Details

The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk, and cognitive performance in active, young, healthy volunteers. The main questions it aims to answer are: 1. Does one-week of creatine supplementation alter urinary markers of inflammation (cytokines) during exercise in the heat when compared to placebo? 2. Does one-week of creatine supplementation alter markers of AKI during exercise in the heat when compared to placebo? 3. Does one-week of creatine supplementation attenuate reductions in cognitive measures as a response of fatigue from exertional heat stress. Researchers will compare creatine monohydrate to a placebo (maltodextrin) to see if it alters inflammation, risk of acute kidney injury, and cognition after exercise in the heat. Participants will : * Complete a baseline aerobic exercise test to measure VO2max * Ingest 20 grams per day of creatine monohydrate or placebo (maltodextrin) for seven consecutive days * Cycle for 90 minutes in a heated chamber (38 C, \~40% relative humidity), alternating low- and high-intensity exercise * Self-collect urine before, after, and one-hour after exercise * Self-insert a rectal thermistor to measure core temperature * Complete cognitive tasks using the NIH toolbox before and after exercise to assess cognition * Complete the other condition (placebo or creatine) at least 21 days later

Key Dates

Start date
Mar 12, 2026
Status verified
Mar 2026
Primary completion
Mar 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Creatine Monohydrate
    Participants will ingest 20 grams per day of creatine monohydrate for 7 days, then 1 day of 5 grams before the exertional heat trial.
  • Placebo Comparator: Placebo (Maltodextrin)
    Participants will ingest 20 grams per day of maltodextrin for 7 days, then 1 day of 5 grams before the exertional heat trial.

Primary Outcome Measure

Change in Urine Biomarker of Acute Kidney Injury Risk from Creatine Use Prior to Exercise in the Heat (The mathematical product of IGBFP7 and TIMP-2 [IGFBP7 x TIMP-2; NephroCheck®]) [ Time Frame: Change in urinary IGBP7 x TIMP-2 from immediately before exercise in the heat to 1 hour after exercise in the heat. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wellness and Recreation CenterCedar FallsIowa50614
Jonathan Assistant Professor, PhD
[email protected]
563-513-7807

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By research site
Wellness and Recreation Center· Cedar Falls, IA

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