ASTX727 & Retifanlimab-dlwr for Advanced Merkel Cell After Progression on Anti-PD-(L)1

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT07472322
Phase
PHASE1/PHASE2
Status
Not Yet Recruiting

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Conditions

  • Merkel Cell Carcinoma
  • Merkel Cell Carcinoma, Stage III
  • Merkel Cell Carcinoma, Stage IV

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The goal of this clinical trial is to learn if ASTX727 can be combined with retifanlimab to treat Merkel cell cancer. It will also learn about the safety of combining these drugs. The main questions it aims to answer are: * Can the combination shrink cancer and lower the chance of the cancer growing or spreading? * Is the combination better than standard of care for Merkel cell cancer? Participants will: * Take oral ASTX727 and retifanlimab through a vein in the arm for about 2 years. * Visit the clinic once every 2 weeks for checkups and tests

Key Dates

Start date
Jun 30, 2026
Status verified
Mar 2026
Primary completion
May 31, 2031
Completion
May 31, 2031

Study Design

Enrollment
31 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Merkel cell carcinoma
    Participants with unresectable Merkel cell carcinoma who progressed on prior PD-1 or PD-L1 inhibitor

Primary Outcome Measure

Percentage of subjects with treatment-emergent adverse events [ Time Frame: Up to 27 months (2 years plus 90 days) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Wisconsin-Carbone Cancer CenterMadisonWisconsin53792
Cancer Connect
[email protected]
(800) 622-8922
Renae Quale, RN
[email protected]

Find similar trials in Madison, WI

By research site
University of Wisconsin-Carbone Cancer Center· Madison, WI

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