Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms

Part of paid clinical trials in Kansas City, Kansas.

Sponsor
University of Kansas Medical Center
Study ID
NCT07472088
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • WBCT — RADIATION
    Images of the knee will be acquired using a WBCT, which provides a three-dimensional view of the patellofemoral joint in a loaded configuration.

Study Details

Patellofemoral joint (PFJ) pain is a common, often chronic, aching pain behind or around the kneecap, frequently called "runner's knee". It occurs when the kneecap does not glide smoothly over the thigh bone, often due to muscle weakness or overuse. It makes sitting for long periods, climbing stairs, or kneeling painful. Symptomatic knee osteoarthritis (OA) is a common, long-term condition where the protective cartilage in the knee joint wears away, causing the bones to rub together, leading to daily pain and stiffness. In simple terms, it is a "wear-and-tear" disease of the entire joint that makes walking, climbing stairs, or bending the knee difficult. The PFJ is where the patella (kneecap) meets the femoral trochlea (front part of the lower thigh bone) at the front of the knee. Patellar tracking refers to the movement of the patella that begins to engage in the distal femoral trochlear groove (smooth, U-shaped groove at the bottom of the thigh bone). By doing this study, we hope to advance clinical knowledge of the PTJ features in a more natural position by using weight-bearing computed tomography (WBCT) images while the leg is straight and slightly bent. Determining links between specific knee symptoms and the PTJ structure on WBCT images could enable providers to effectively target the underlying causes and to develop targeted treatments.

Key Dates

Start date
Apr 29, 2026
Status verified
May 2026
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
36 participants (estimated)

Arms

  • Arm: PFJ pain
    Participants experiencing recurrent, atraumatic patella dislocation, knee pain isolated to the anterior region, or PFPS (pain around the patella, exacerbated by prolonged positioning or ascending/descending stairs)
  • Arm: Symptomatic knee OA
    Participants experiencing pain in any other area of the knee, including the anterior region in combination with other regions

Primary Outcome Measure

TT-TG [ Time Frame: From enrollment to end of study (1 day) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Kansas Medical CenterKansas CityKansas66160
Jessica Lee, PhD
[email protected]
913-574-0961
Yashaf Zaheer, MD
[email protected]
Neil A Segal, MD, MS (PRINCIPAL_INVESTIGATOR)
Yashaf Zaheer, MD (SUB_INVESTIGATOR)

Find similar trials in Kansas City, KS

By condition
Osteoarthritis (other)
By specialty
OrthopedicsMusculoskeletal disorders
By research site
University of Kansas Medical Center· Kansas City, KS

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