A Study to Evaluate the Safety and Efficacy of Intracranial Venous Blood Sampling for Liquid Biopsy in the Diagnosis of Brain Cancers

Part of paid clinical trials in Houston, Texas.

Sponsor: M.D. Anderson Cancer Center
Study ID: NCT07467109
Status: Not Yet Recruiting

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Conditions

Brain Cancers
Evaluate the Safety
Intracranial Venous Blood
Liquid Biopsy

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

blood sampling — DIAGNOSTIC_TEST
Done by IV

Study Details

To learn if drawing blood directly from veins inside the brain is safe and can effectively provide the same kind of detailed information about high-grade glioma as traditional surgical biopsy.

Key Dates

Start date: Aug 19, 2026
Status verified: Mar 2026
Primary completion: May 1, 2027
Completion: May 1, 2029

Study Design

Enrollment: 20 participants (estimated)

Arms

Arm: Intracranial Venous Blood Sampling With BBB Disruption
Comparisons will be made between the peripheral, intracranial venous blood and intracranial arterial blood, before and after BBB disruption to evaluate the amount of ctDNA and the degree of concordance between molecular markers for tumor diagnosis.

Primary Outcome Measure

safety and adverse events (AEs). [ Time Frame: Through study completion; an average of 1 year ]

Central Contacts

Christopher C Young, MD
713-745-4243
[email protected]

Locations (1)

Facility	City	State	ZIP	Site coordinators
MD Anderson Cancer Center	Houston	Texas	77030	Christopher C Young, MD [email protected] 713-745-4243 Christopher C Young, MD (PRINCIPAL_INVESTIGATOR)

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By research site

MD Anderson Cancer Center· Houston, TX