Mobile Vehicle-Based Delivery of Lenacapavir Pre-Exposure Prophylaxis in Los Angeles County

Part of paid clinical trials in Santa Monica, California.

Sponsor
University of California, Los Angeles
Study ID
NCT07467018
Status
Recruiting
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Conditions

  • HIV Prevention

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Community-based healthcare delivery — OTHER
    This study evaluates the implementation strategy of community-based delivery of HIV biomedical prevention with lenacapavir.
  • Lenacapavir — DRUG
    Mobile, community-based delivery of lenacapavir

Study Details

This project evaluates the implementation strategy of the delivery of lenacapavir pre-exposure prophylaxis (LEN PrEP) - a newly available long-acting, injectable medication for human immunodeficiency virus (HIV) prevention - via a mobile health van model for people who are unstably housed in Los Angeles County (LAC). People who are unhoused or are facing housing instability experience significant barriers to accessing HIV prevention care in traditional clinic settings. In 2022, approximately 13% of newly diagnosed HIV cases in LAC were experiencing homelessness, a 36% increase over the prior period. The study will work with the University of California, Los Angeles (UCLA) Health's Homeless Healthcare Collaborative (HHC), which operates mobile health vans staffed by clinicians, social workers, and community health workers, to bring LEN PrEP directly to community settings, such as shelters, encampments, community centers, and transitional housing facilities. This study has three primary aims: 1. Characterize uptake of LEN PrEP among unstably housed people in LAC receiving health services via HHC's mobile program. 2. Evaluate how many study participants stay on LEN PrEP through 52 weeks. 3. Understand costs, acceptability, and sustainability of the mobile LEN PrEP delivery model.

Key Dates

Start date
Apr 21, 2026
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Primary Cohort
    Unstably housed adults without HIV being reached for healthcare by the UCLA Health Homeless Healthcare Collaborative

Primary Outcome Measure

Uptake of LEN PrEP [ Time Frame: 3 months after enrollment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCLA Health Homeless Healthcare CollaborativeSanta MonicaCalifornia90404
Brian Zunner-Keating, RN, PHNA-BC
[email protected]
310-562-1871

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By research site
UCLA Health Homeless Healthcare Collaborative· Santa Monica, CA

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