Veteran's Interdisciplinary Care for Traumatic Brain Injury and Co-Occurring Disorders Rehabilitation Trial

Conditions

• Traumatic Brain Injury and Co-occurring Disorders

Eligibility Criteria

Sex

ALL

Age

18 Years - 65 Years

Healthy Volunteers

Not accepted

Interventions

• 3-week interdisciplinary outpatient rehab program (IORP) — BEHAVIORAL
  Interdisciplinary outpatient rehabilitation program (IORP) for military veterans and first responders experiencing chronic effects of traumatic brain injury (TBI) and co-occurring disorders (e.g., posttraumatic stress disorder, depression, substance use).

Study Details

The goal of this clinical trial is to learn if the Avalon Action Alliance Interdisciplinary Outpatient Rehabilitation Program (IORP) can reduce long-lasting symptoms of traumatic brain injury (TBI) and co-occurring disorders in veterans and first responders. The main questions it aims to answer are: * Does a 3-week IORP reduce symptoms of long-lasting TBI and co-occurring disorders in military veterans and first responders? * Does the 3-week IORP improve life quality and function in military veterans and first responders? Researchers will compare the Control group to the Invention group to see if a 3-week of IORP reduced symptoms of TBI and co-occurring disorders in military veterans and first responders. Participants will complete the following activities. The items with an asterisk(\*) are not required or available at all sites. * Answer online survey questions about their TBI symptoms, life satisfaction, and life activities * Complete two blood draws\* * Complete two magnetic resonance imaging (MRI) brain scans\*

Key Dates

Start date

Mar 26, 2026

Status verified

Mar 2026

Primary completion

Feb 28, 2029

Completion

May 31, 2029

Study Design

Enrollment

416 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Other: Interdisciplinary Outpatient Rehabilitation Program Intervention Arm
  Participants in this arm will start the 3-Week TBI IORP after baseline evaluation and receiving the recommendation to participate in the IORP.
• Other: Control Waiting Period Arm
  Participants in this arm will start the 3-Week TBI IORP after observing at least a 3 month waiting period after baseline evaluation and receiving the recommendation to participate in the IORP.

Primary Outcome Measure

Mean change in Neurobehavioral Symptom Inventory (NSI) [ Time Frame: Baseline enrollment to 3-month follow-up (post IORP) ]

Locations (1)

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