Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT07462507
Phase
PHASE2
Status
Recruiting
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Conditions

  • Brain Metastases
  • Central Nervous System Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • [C-11]-CS1P1 — DRUG
    * The investigational radiotracer \[C-11\]-CS1P1 is an S1P1 PET imaging agent. * The PET imaging will be acquired either in a PET/MR scanner or the PET/CT scanner
  • Brain MRI — DEVICE
    Optional

Study Details

Adult patients with primary or secondary central nervous system malignancies will be invited to undergo a baseline \[C-11\]-CS1P1 PET scan and a follow-up scan within 24 months of the baseline scan (preferably within 6-months post-treatment).The study will describe patterns of tracer uptake in tumors and normal brain and explore how these patterns relate to MRI findings, treatments received, and clinical outcomes.

Key Dates

Start date
Apr 16, 2026
Status verified
Apr 2026
Primary completion
Jun 30, 2031
Completion
Jun 30, 2033

Study Design

Enrollment
104 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: [C-11]-CS1P1 PET
    C-11\]-CS1P1 PET image acquisition up to 90 minutes will be acquired at baseline and at follow-up visit within 24 months (preferably within 6 months post treatment), along with an optional brain MRI.

Primary Outcome Measure

[C-11]CS1P1 Standardized uptake value (SUV) ratio of tumor to non-tumor regions of interest (ROIs) [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington University School of MedicineSt LouisMissouri63110
Tammie L.S. Benzinger, M.D., Ph.D.
[email protected]
314-362-1558
Jayashree Rajamanickam
[email protected]
314-273-6140
Tammie L.S. Benzinger, M.D., Ph.D. (PRINCIPAL_INVESTIGATOR)
Hongyu An, Ph.D. (SUB_INVESTIGATOR)
G. Richard Benzinger, M.D., Ph.D. (SUB_INVESTIGATOR)
Matthew R Brier, M.D., Ph.D. (SUB_INVESTIGATOR)
Yong Wang, Ph.D. (SUB_INVESTIGATOR)
Qing Wang, Ph.D. (SUB_INVESTIGATOR)
Jiayi Huang, M.D. (SUB_INVESTIGATOR)
Zhude Tu, Ph.D. (SUB_INVESTIGATOR)
Richard Laforest, Ph.D. (SUB_INVESTIGATOR)
C. Ryan King, M.D., Ph.D. (SUB_INVESTIGATOR)
Esther Lu, Ph.D. (SUB_INVESTIGATOR)

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By research site
Washington University School of Medicine· St Louis, MO

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