Psilocybin Microdosing on Cognition, Mood and Quality of Life

Conditions

• Psychedelic Microdosing Effects on Mood, Cognition, Subjective Well-being and MRI

Eligibility Criteria

Sex

ALL

Age

21 Years - 40 Years

Healthy Volunteers

Accepted

Interventions

• Psliocybin — DRUG
  2.0mg powdered psilocybin derived from Psilocybe cubensis mushrooms, in capsules, provided three times weekly for four weeks
• Placebo — DRUG
  0mg matching capsules, provided three times weekly for four weeks

Study Details

This study is being conducted to evaluate how of 30 days of intermittently microdosed psilocybin affects mood, cognition, subjective well-being and structural/functional MRI results compared to a placebo. Investigators hypothesize that compared to placebo, 30 days of intermittently microdosed psilocybin will produce observable changes in mood, cognition, subjective well-being and MRI, in the absence of psychedelic experiences.

Key Dates

Start date

Apr 1, 2026

Status verified

Feb 2026

Primary completion

Apr 1, 2028

Completion

Apr 1, 2028

Study Design

Enrollment

20 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Active Comparator: Psychedelic group
  An imperceptible dose of psilocybin in capsules will be administered to subjects three times weekly for four weeks. Assessments will be conducted once weekly. After 30 days of a steady dose of psilocybin, subjects will be re-assessed with baseline measures.
• Placebo Comparator: Placebo group
  An dose of placebo in capsules, identical to the active, will be administered to subjects three times weekly for four weeks. Assessments will be conducted once weekly. After 30 days of a steady dose of psilocybin, subjects will be re-assessed with baseline measures.

Primary Outcome Measure

The Complex Working Memory Span (CWMS) Task- fMRI measure [ Time Frame: From enrollment to end of treatment at 8 weeks. ]

Central Contacts

• Godfrey Pearlson, MD
  860-545-7757
  [email protected]

Locations (1)

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