Mind After Midnight

Part of paid clinical trials in Tucson, Arizona.

Sponsor
University of Arizona
Study ID
NCT07438912
Status
Recruiting
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Conditions

  • Circadian Rhythm Disorders
  • Sleep Deprivation
  • Sleep Wake Disorders
  • Suicidal Ideation

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • Sleep Pressure Manipulation — BEHAVIORAL
    Participants undergo an experimental manipulation of homeostatic sleep pressure involving controlled wakefulness or scheduled awakening during the biological night. Mood, suicidal ideation, impulsivity, and decision-making are assessed during overnight laboratory sessions.

Study Details

This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts. Adults with a history of suicidal ideation in the past six months will complete laboratory and home-based assessments under varying levels of sleep pressure. Participants will be evaluated during late-night wakefulness and under conditions of both higher and lower sleep pressure. The goal of the study is to better understand the biological and behavioral mechanisms that may contribute to elevated suicide risk during nocturnal wakefulness.

Key Dates

Start date
Mar 6, 2026
Status verified
May 2026
Primary completion
Feb 28, 2029
Completion
Aug 31, 2029

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: High Sleep Pressure Condition
    Participants will remain awake until 2:00 AM to induce high homeostatic sleep pressure. During the biological night (2:00-4:00 AM), participants will complete assessments of mood, suicidal ideation, impulsivity, and decision-making under conditions of sustained wakefulness.
  • Experimental: Low Sleep Pressure Condition
    Participants will be allowed to sleep and will be awakened at 2:00 AM to induce lower homeostatic sleep pressure. During the biological night (2:00-4:00 AM), participants will complete assessments of mood, suicidal ideation, impulsivity, and decision-making following sleep and acute awakening.

Primary Outcome Measure

Feelings of Hopelessness [ Time Frame: Visit 1(day 2, night 2), Visit 2 (day 2, night 2) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Arizona - Center for Sleep, Circadian, and Neuroscience ResearchTucsonArizona85724
Darilyn Rivera-Collazo, MS
[email protected]
520-626-4746

Find similar trials in Tucson, AZ

By research site
University of Arizona - Center for Sleep, Circadian, and Neuroscience Research· Tucson, AZ

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