PRF + Minocycline vs Arestin in Non-surgical Perio Therapy

Conditions

• Non-surgical Periodontal Therapy

Eligibility Criteria

Sex

ALL

Age

N/A - N/A

Healthy Volunteers

Accepted

Interventions

• Arestin — DRUG
  Arestin evaluated as an adjunct to non-surgical therapy
• PRF + M — BIOLOGICAL
  PRF with Minocycline evaluated as an adjunct to non-surgical therapy

Study Details

Periodontitis is a chronic, biofilm-modulated inflammatory disease characterized by microbial dysbiosis and a dysregulated host immune response, eventually resulting in the gradual breakdown of the periodontal attachment apparatus. While non-surgical periodontal therapy (NSPT) remains the first choice of treatment, its capability to completely resolve inflammation and pocketing in moderate disease severity may be limited, supporting the use of adjunctive antimicrobial or biologic interventions. Platelet-rich fibrin (PRF) and locally administered antibiotics, including minocycline, have individually shown clinical advantages; nonetheless, evidence assessing their combined utility remains unexplored. This split-mouth randomized controlled clinical trial (RCT) aims to compare the clinical efficacy of PRF combined with minocycline versus minocycline microspheres hydrochloride (Arestin) as adjuncts to NSPT in patients with Stage II or III, Grade A or B periodontitis.

Key Dates

Start date

Dec 1, 2024

Status verified

May 2026

Primary completion

Dec 1, 2025

Completion

Dec 30, 2025

Study Design

Enrollment

15 participants (actual)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: Arestin Group
  Arestin placed interproximal sites after non-surgical therapy
• Active Comparator: PRF + M Group
  PRF with Minocycline placed interproximal sites after non-surgical therapy

Primary Outcome Measure

Clinical Attachment Loss [ Time Frame: 6 months ]

Locations (1)

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