Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department

Part of paid clinical trials in Camden, New Jersey.

Sponsor
The Cooper Health System
Study ID
NCT07430345
Phase
PHASE1/PHASE2
Status
Not Yet Recruiting

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Conditions

  • Fracture

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Buprenorphine 0.15 MG — DRUG
    given every 15 minutes as needed for numerical pain score 4 or greater for a maximum of three doses
  • Hydromorphone 0.25 mg IV — DRUG
    given every 15 minutes as needed for numerical pain score 4 or greater for a maximum of three doses

Study Details

The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are: Is buprenorphine as effective as opioids to treat pain? Are there less side effects with buprenorphine? Researchers will compare buprenorphine and hydromorphone to see if there are differences in pain control and side effects. Participants will be given one of the two study drugs after breaking a bone and asked about their pain scores and side effects for the next 48 hours.

Key Dates

Start date
Apr 30, 2026
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Jan 31, 2027

Study Design

Enrollment
48 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Hydromorphone
    0.25mg hydromorphone IV given every 15 minutes as needed for numerical pain score 4 or greater for a maximum of three doses
  • Experimental: Buprenorphine
    0.15mg buprenorphine IV given every 15 minutes as needed for numerical pain score 4 or greater for a maximum of three doses

Primary Outcome Measure

Difference in pain scores [ Time Frame: 4 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cooper University HospitalCamdenNew Jersey08103
Katherine Selman, MD
[email protected]
856-342-2627

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By research site
Cooper University Hospital· Camden, NJ

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