Finger Plethysmography to Predict Fluid Responsiveness in Healthy Pregnancy and Severe Preeclampsia

Part of paid clinical trials in Palo Alto, California.

Sponsor
Stanford University
Study ID
NCT07430254
Status
Not Yet Recruiting

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Conditions

  • Pre-Eclampsia, Severe
  • Pregnancy

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Noninvasive finger plethysmographic cardiac output monitoring — DIAGNOSTIC_TEST
    Noninvasive hemodynamic monitoring used to assess changes in cardiac output for prediction of fluid responsiveneness
  • Standard transthoracic echocardiographic assessment — DIAGNOSTIC_TEST
    Noninvasive hemodynamic monitoring (echocardiography) used to assess changes in cardiac output for prediction of fluid responsiveness

Study Details

The goal of this observational study is to determine whether noninvasive finger plethysmographic cardiac output monitoring can help predict fluid responsiveness in pregnant women, including those with preeclampsia with severe features. The main questions it aims to answer are : * Can changes in cardiac output measured by finger plethysmography predict fluid responsiveness? * How does this method perform compared with standard echocardiographic assessment? Participants will provide consent and undergo noninvasive hemodynamic monitoring and a brief reversible physiological challenge.

Key Dates

Start date
Jul 1, 2026
Status verified
Feb 2026
Primary completion
Jul 1, 2028
Completion
Jul 1, 2028

Study Design

Enrollment
88 participants (estimated)

Arms

  • Arm: Healthy pregnant women
    Pregnant participants without hypertensive disorders enrolled for brief, noninvasive hemodynamic assessments
  • Arm: Preeclampsia With Severe Features
    Women diagnosed with preeclampsia with severe features enrolled for brief, noninvasive hemodynamic assessments

Primary Outcome Measure

Prediction Accuracy for Change in Cardiac Output for Fluid Responsiveness [ Time Frame: Baseline (semi-recumbent) and 1 minute after passive leg raising ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Lucile Packard Children's HospitalPalo AltoCalifornia94304-

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By research site
Lucile Packard Children's Hospital· Palo Alto, CA

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