Ventilation and Perfusion in Asthmatics

Part of paid clinical trials in Miami, Florida.

Sponsor
University of Miami
Study ID
NCT07426458
Phase
PHASE4
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Albuterol Sulfate — DRUG
    Visit 1: Albuterol Sulfate (90mcg) two puffs will be administered via metered-dose inhaler (MDI) with spacer during the baseline study visit to obtain baseline imaging values.
  • Albuterol-Budesonide — DRUG
    Visit 2: AIRSUPRA (Albuterol/Budesonide) (90mcg/80mcg) two puffs will be administered via MDI with spacer during this study visit. This intervention is used to evaluate its effect on ventilation defect percentage (VDP), ventilation heterogeneity (VH), and perfusion metrics derived from XV LVAS imaging

Study Details

Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation (V-distribution), ventilation defect percentage (VDP), and ventilation heterogeneity (VH).

Key Dates

Start date
Apr 27, 2026
Status verified
Apr 2026
Primary completion
Apr 30, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Albuterol Sulfate followed by AIRSUPRA (Albuterol/Budesonide)
    All participants in this single-arm study will complete 2 study visits, each lasting approximately 1 hour. Interventions will be administered in a sequential order. * Visit 1: Participants will inhale Albuterol Sulfate via metered-dose inhaler (MDI) with spacer * Visit 2: Participants will inhale AIRSUPRA (Albuterol/Budesonide) via metered-dose inhaler (MDI) with spacer as the second stage of treatment.

Primary Outcome Measure

Change in Regional Ventilation [ Time Frame: Baseline, 30 minutes after budesonide administration ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Miami - Converge MiamiMiamiFlorida33136
Tiffany Salcito
[email protected]
305-243-2568
Trishul Siddharthan, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Miami, FL

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
University of Miami - Converge Miami· Miami, FL

Related Studies