Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT07426016
Status
Not Yet Recruiting

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Conditions

  • Respiratory Distress Syndrome (Neonatal)
  • Surfactant Deficiency Syndrome Neonatal

Eligibility Criteria

Sex
ALL
Age
0 Hours - 3 Days
Healthy Volunteers
Not accepted

Interventions

  • Video Laryngoscopy — PROCEDURE
    Video Laryngoscopy will be used to visualize the vocal cords and place the LISA catheter
  • Direct Laryngoscopy — PROCEDURE
    Direct Laryngoscopy will be used to visualize the vocal cords and place the LISA catheter

Study Details

Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs. The goal of the study is to compare the use of video-based visualization to direct visualization during a procedure called less invasive surfactant administration (LISA). The main questions the study aims to answer are: 1) does one method of visualization have a increased rate of giving the medicine successfully on the first attempt? 2) what benefits are there of each method?

Key Dates

Start date
Jun 30, 2026
Status verified
May 2026
Primary completion
Jun 30, 2028
Completion
Nov 30, 2028

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Video Laryngoscopy
    A video laryngoscopy will be used to visualize the vocal cords and place the LISA catheter for surfactant administration
  • Active Comparator: Direct Laryngoscopy
    Direct laryngoscopy (no camera) will be used to visualize the vocal cords and place the LISA catheter for surfactant administration

Primary Outcome Measure

Rate of first attempt success [ Time Frame: During procedure ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Parkland HospitalDallasTexas75235
Office of Research Administration
[email protected]
214-645-8300
Riti Chokshi, MD (PRINCIPAL_INVESTIGATOR)
Shalini Ramachandram, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Parkland Hospital· Dallas, TX

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