Representation of Spatiotemporal Information in Human Episodic Memory and Navigation

Conditions

• Schema to Organize Memory or no Schema
• Scopolamine or Placebo

Eligibility Criteria

Sex

ALL

Age

18 Years - 40 Years

Healthy Volunteers

Accepted

Interventions

• Scopolamine — DRUG
  effects of scopolamine on brain oscillations, navigation, and memory

Study Details

Neural diseases such as stroke can have distinct effects on the ability to navigate and orient compared to remembering daily events like when one last took medicine. This proposal seeks test rival hypotheses regarding the neural mechanisms underlying commonalities and differences in navigation and event-related memory, particularly as they relate to pre-existing knowledge. Such mechanistic insight could help inspire therapies that could be used to bolster intact brain function in a compensatory manner following strokes or other neural insults.

Key Dates

Start date

Apr 1, 2025

Status verified

Feb 2026

Primary completion

Mar 29, 2030

Completion

Mar 29, 2030

Study Design

Enrollment

15 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Patients undergoing surgical monitoring to plan resections for epilepsy
  Patients will have electrodes implanted in their hippocampus for surgical monitoring allowing for direct recordings. Patients will receive scopolamine on one day and placebo on another.

Primary Outcome Measure

behavioral: navigational accuracy [ Time Frame: from enrollment to end of study (3 days) ]

Locations (2)

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