Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT-2 Inhibitors

Part of paid clinical trials in Orlando, Florida.

Sponsor: AdventHealth Translational Research Institute
Study ID: NCT07421518
Phase: PHASE2
Status: Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex: ALL
Age: 18 Years - 40 Years
Healthy Volunteers: Accepted

Interventions

SGLT-2 inhibitor (Sotagliflozin) — DRUG
Participants will be asked to take the SGLT-2 inhibitor.
Insulin withdrawal test (IWT) — OTHER
An Insulin withdrawal test (IWT) will be given to participants on an SGLT-2 inhibitor. Participants will be monitored.

Study Details

The purpose of this research is to see how well a special education plan using continuous ketone monitoring (DGK) works to lower the risk of a condition called diabetic ketoacidosis (DKA) in people with type 1 diabetes (T1D) taking SGLT2 inhibitors (a type of medication commonly used to treat type 2 diabetes). This special education plan is compared to a general education plan and considers the higher risk of DKA when using medicines like SGLT2 inhibitors.