The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers

Part of paid clinical trials in Miami, Florida.

Sponsor
University of Miami
Study ID
NCT07415707
Status
Recruiting
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Conditions

  • Aging
  • Alcohol Drinking

Eligibility Criteria

Sex
ALL
Age
65 Years - 84 Years
Healthy Volunteers
Not accepted

Interventions

  • Visbiome — DIETARY_SUPPLEMENT
    Participants will receive 900 billion Colony Forming Units (CFU) once daily for 30 days
  • Motivational Interviewing — BEHAVIORAL
    Participants will receive one counseling session at baseline via video call, lasting up to 30 minutes
  • Placebo — OTHER
    Participants will receive a standard placebo designed to resemble the probiotic once daily for 30 days

Study Details

The goal of this pilot study is to explore a combination of two interventions: (1) a behavioral alcohol-reduction intervention using motivational interviewing, and (2) a blinded probiotic microbiome or placebo intervention. The study examines whether these interventions improve cognitive and neurophysiological function, including brain metabolism, in older adults who are high-risk alcohol drinkers.

Key Dates

Start date
Feb 26, 2026
Status verified
Mar 2026
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Motivational Interviewing + Probiotic
    Participants in this arm will be given a brief motivational interview to promote drinking reduction. During the 30-day intervention, participants will receive an active probiotic supplement 900 billion colony forming units (CFU), once daily.
  • Placebo Comparator: Motivational Interviewing + Placebo
    Participants in this arm will be given a brief motivational interview to promote drinking reduction. During the 30-day intervention, participants will receive a placebo supplement once daily.

Primary Outcome Measure

Change in Total Cognition Composite score [ Time Frame: Baseline, 30 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MiamiMiamiFlorida33136
Teddy Salan, PhD
[email protected]
305-243-9228
Teddy Salan, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Miami· Miami, FL

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