Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)

Part of paid clinical trials in New York, New York.

Sponsor
Columbia University
Study ID
NCT07410481
Status
Recruiting
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Conditions

  • Cardiac Arrest (CA)
  • PTSD - Post Traumatic Stress Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 81 Years
Healthy Volunteers
Not accepted

Interventions

  • Acceptance and Mindfulness Based Exposure Therapy — BEHAVIORAL
    Eight sessions of exposure therapy combined with mindfulness delivered via videoconferencing platform. AMBET will consist of 90-minute weekly sessions for 4 weeks, then every other week for 4 more sessions.
  • Present-Centered Therapy — BEHAVIORAL
    Twelve 60-minute weekly sessions of psychotherapy delivered via videoconferencing platform.

Study Details

The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest. This study will compare AMBET to another psychotherapy treatment called Present Centered Therapy (PCT) to see which therapy is more effective in treating PTSD. The main questions it aims to answer are: Does AMBET reduce PTSD symptoms in survivors of cardiac arrest? How do the benefits of AMBET compare to PCT? Participants will: * Be randomly assigned to receive either AMBET or PCT * Attend 12 hours of individual psychotherapy sessions over about 12 weeks * Complete short weekly surveys about their mood and behaviors online * Wear a Fitbit device to track sleep and activity during the study * Do brief homework assignments between sessions

Key Dates

Start date
Mar 31, 2026
Status verified
Apr 2026
Primary completion
Jun 30, 2028
Completion
Mar 31, 2029

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Acceptance- and mindfulness-based exposure therapy (AMBET)
    Remotely delivered psychotherapy combining exposure therapy with mindfulness.
  • Active Comparator: Present-Centered Therapy (PCT)
    Remotely delivered psychotherapy that focuses on increasing adaptive responses to current life stressors and difficulties.

Primary Outcome Measure

Change in PTSD symptoms over time [ Time Frame: Baseline, At 6 weeks, Post-treatment: Approximately 3 months and 6 months from intake ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical CenterNew YorkNew York10032
Maja Bergman, Ph.D.
[email protected]
Yuval Neria (PRINCIPAL_INVESTIGATOR)

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By research site
Columbia University Irving Medical Center· New York, NY

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