Neurophysiology of Reward Signaling in Parkinson's Disease

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT07409207
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
40 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Neurophysiology recordings — OTHER
    Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated
  • Neural stimulation — OTHER
    Neural stimulation will be delivered during a gambling task and its impact on task performance quantified

Study Details

The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Key Dates

Start date
Sep 1, 2024
Status verified
Feb 2026
Primary completion
Sep 30, 2029
Completion
Sep 30, 2029

Study Design

Enrollment
75 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Neural recordings and stimulation

Primary Outcome Measure

Changes in caudate DLPFC beta coherence [ Time Frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt University Medical CenterNashvilleTennessee37212
Isabel Long, BS
[email protected]
615-421-3046
Sarah Bick, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Nashville, TN

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
Vanderbilt University Medical Center· Nashville, TN

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