Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT07408076
Phase
PHASE1/PHASE2
Status
Not Yet Recruiting

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Conditions

  • Kidney Stones, Urolithiasis, Hypocitraturia
  • Nephrolithiasis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Potassium Citrate — DRUG
    20 mEq Kcit twice a day (40 mEq daily
  • Sodium Bicarbonate — DRUG
    650 mg sodium bicarbonate twice a day (35.2 mEq daily)

Study Details

Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications. Prescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and/or decrease the risk of future kidney stones. However, efficacy of alternatives to potassium potassium citrate are not well studied. This study seeks to evaluate sodium bicarbonate and assess its ability to alkalinize urine in a cohort of patients with kidney stones and compare this to prescription potassium citrate.

Key Dates

Start date
Feb 1, 2026
Status verified
Jan 2026
Primary completion
Aug 1, 2026
Completion
Feb 1, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Sodium Bicarbonate -> Potassium Citrate
    Receives 1 week of sodium bicarbonate, then 1 week of potassium citrate after washout.
  • Experimental: Potassium Citrate -> Sodium Bicarbonate
    1 week of potassium citrate first, then sodium bicarbonate after a washout.

Primary Outcome Measure

Change in 24-Hour Urinary Citrate Excretion from 24-Hour Urine Collection [ Time Frame: 14 days ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
University of California, Los AngelesLos AngelesCalifornia90095-
University of California, DavisSacramentoCalifornia95817
Noah Canvasser
University of California, San DiegoSan DiegoCalifornia92103
Seth Bechis
Brigham & Women'sBostonMassachusetts02115
Daniel Wolen

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By research site
University of California, Los Angeles· Los Angeles, CAUniversity of California, Davis· Sacramento, CAUniversity of California, San Diego· San Diego, CABrigham & Women's· Boston, MA

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