HMPL-A580 in Participants With Advanced or Metastatic Solid Tumor

Part of paid clinical trials in Orange, California.

Sponsor
Hutchmed
Study ID
NCT07396584
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Solid Tumors, Adult

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • HMPL-A580 — DRUG
    Part A(Phase I) Dose Escalation Enrolled participants will receive HMPL-A580 treatment in a dose escalation setting initially at 6 predefined dose levels.
  • HMPL-A580 — DRUG
    Part B(Phase IIa) Dose Expansion/Dose Optimization Evaluate the safety and preliminary anti-tumor activity of HMPL-A580 in selected solid tumors.

Study Details

This is a first-in-human, multicenter, open-label, phase I/Ⅱa clinical study of HMPL-A580 in participants with unresectable, advanced or metastatic solid tumors.

Key Dates

Start date
Mar 4, 2026
Status verified
Mar 2026
Primary completion
Dec 31, 2028
Completion
Jan 30, 2029

Study Design

Enrollment
186 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Part A(Phase I) Dose Escalation
  • Experimental: Part B(Phase IIa) Dose Expansion/Dose Optimization

Primary Outcome Measure

Maximum Tolerated Dose (MTD) and/or recommended dose(s) for expansion(RDE) [ Time Frame: Approximately 12 months ]

Locations (5)

FacilityCityStateZIPSite coordinators
University of California Irvine Medical CenterOrangeCalifornia92868
Zhaohui Liao Arter
[email protected]
714-456-6244
BRCR GlobalPlantationFlorida33324
Sumit Sawhney
[email protected]
561-447-0614
Florida Clinical Trials Group LLC (Plantation)PlantationFlorida33324
Harshad Amin
[email protected]
772-297-3057
Florida Clinical Trials Group LLC (Tamarac)TamaracFlorida33319
Chintan Gandhi
[email protected]
772-297-3057
University of Washington/Fred Hutchinson Cancer CenterSeattleWashington98109
Lei Deng
[email protected]
206-606-7017

Find similar trials in Orange, CA

By research site
University of California Irvine Medical Center· Orange, CABRCR Global· Plantation, FLFlorida Clinical Trials Group LLC (Plantation)· Plantation, FLFlorida Clinical Trials Group LLC (Tamarac)· Tamarac, FLUniversity of Washington/Fred Hutchinson Cancer Center· Seattle, WA

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