ALDH2 Genetic Testing in East Asian Community

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Northwestern University
Study ID
NCT07392775
Status
Not Yet Recruiting

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Conditions

  • Flushing
  • Healthy Adult

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Genetic Test Results Return — BEHAVIORAL
    Returning genetic test results for alcohol flushing genes (i.e., ALDH2, ADH1B)
  • Alcohol Flushing Education — BEHAVIORAL
    Administering alcohol flushing educational module.

Study Details

The goal of this clinical trial is to learn whether education plus genetic testing for ALDH2\*2 and ADH1B\*2 is feasible and acceptable and whether it influences modifiable health behaviors in East Asian American adults who experience alcohol flushing when they drink alcohol or have a family history of flushing. The main questions it aims to answer are: 1. Is providing education plus ALDH2\*2/ADH1B\*2 genetic testing feasible and acceptable in a clinical care context? 2. Does receiving genetic testing results plus education lead to changes in modifiable health behaviors compared with education alone? Researchers will compare education plus genetic testing (intervention arm) to education only (control arm) to see if adding genetic testing improves feasibility/acceptability and supports health behavior change. Participants will: 1. Complete an education module about alcohol flushing and ALDH2/ADH1B 2. Be randomized to either: (A) Receive genetic testing for ALDH2\*2 and ADH1B\*2 with results disclosure, or (B) Receive education only. 3. Complete follow-up measures about feasibility, acceptability, and modifiable health behaviors

Key Dates

Start date
Sep 1, 2026
Status verified
Jan 2026
Primary completion
Jun 1, 2029
Completion
Jun 30, 2029

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: Alcohol Flushing Education Only
  • Experimental: Alcohol Flushing Education AND Genetic Testing

Primary Outcome Measure

Feasibility of Alcohol Flushing Genetic Testing in Primary Care [ Time Frame: From enrollment to the end of data collection at 8 weeks. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Northwestern University Feinberg School of MedicineChicagoIllinois60611
Jennifer L Young, PhD
[email protected]
6085137862

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By research site
Northwestern University Feinberg School of Medicine· Chicago, IL

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