Functional Impact of Acute Respiratory Viral Infections in Older Adults

Conditions

• Respiratory Infections in Old Age

Eligibility Criteria

Sex

ALL

Age

60 Years - N/A

Healthy Volunteers

Not accepted

Study Details

The prevention of infectious diseases in older adults remains a major public health challenge, as acute respiratory infections are a leading cause of hospitalisation, mortality, and functional decline worldwide. Immunosenescence and environmental exposures increase susceptibility to infection and reduce vaccine effectiveness in this population. Respiratory viruses, including influenza, SARS-CoV-2, respiratory syncytial virus, and human metapneumovirus, account for a substantial share of this burden, much of which is vaccine-preventable. However, their impact on functional decline and recovery in older adults remains insufficiently characterized. This international study aims to assess the effect of hospitalization for major respiratory viral infections on loss of autonomy in individuals aged 60 years and older, to inform targeted prevention and vaccination strategies.

Key Dates

Start date

Jan 15, 2026

Status verified

May 2026

Primary completion

Jan 15, 2028

Completion

Jun 15, 2028

Study Design

Enrollment

1,600 participants (estimated)

Primary Outcome Measure

Evolution of Functional Dependency assessed by Activities of Daily Living (ADL) Score [ Time Frame: Baseline, at hospital discharge, 3 months after discharge, and 6 months after discharge. ]

Central Contacts

• Gaetan GAVAZZI, MD,PhD
  0033(0)476766760
  [email protected]
• Saber TOUATI, PhD
  0033(0)476765805
  [email protected]

Locations (1)

Find similar trials in Rochester, NY