Cardiac Structure and Function in MPS

Conditions

• MPS - Mucopolysaccharidosis
• MPS I
• MPS IV A
• MPS IVA

Eligibility Criteria

Sex

ALL

Age

0 Years - 99 Years

Healthy Volunteers

Accepted

Study Details

The purpose of this study is to better understand how heart and blood vessel problems develop in people with Mucopolysaccharidosis (MPS). The investigators are looking at certain substances in the body called GAGs and proteoglycans to see how they affect the heart. The investigators also want to find reliable blood and urine markers that can help us track heart health and guide future treatments. This study aims to answer two main questions: 1. Do people with MPS show faster changes in their blood vessels over time (such as thickening or stiffening of the carotid artery) compared to people without MPS? 2. Do people with MPS have higher levels of certain proteins in their blood (such as clusterin and inflammatory markers) that are linked to blood vessel changes? What participants will do? Participants will complete the following tests once a year for 4 years: * Carotid ultrasound: an imaging test that looks at the blood vessels in the neck. * Echocardiogram: an ultrasound of the heart. * Blood draw * Urine collection These tests help the investigators track changes in heart and blood vessel health over time.

Key Dates

Start date

Sep 1, 2025

Status verified

Jan 2026

Primary completion

Apr 30, 2030

Completion

Apr 30, 2030

Study Design

Enrollment

240 participants (estimated)

Arms

• Arm: MPS
  Participants diagnosed with MPS I or MPS IVA
• Arm: Control
  Participants who do not have an MPS diagnosis

Primary Outcome Measure

Cardiac and Carotid Structure and Function [ Time Frame: Year 1, Year 2, Year 3, and Year 4 ]

Central Contacts

• Nina Movsesyan
  714-509-3008
  [email protected]

Locations (3)

Find similar trials in Orange, CA

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