Blood Storage Related Mortality and Adverse Effects in Trauma Patients

Conditions

• Blood Product Transfusion for All Conditions
• Major Trauma
• Transfusion Adverse Reaction

Eligibility Criteria

Sex

ALL

Age

18 Years - 75 Years

Healthy Volunteers

Not accepted

Study Details

The purpose of this retrospective study is to examine the following factors related to blood storage time in severely injured trauma patients who received large blood transfusions: 1. The effect of blood storage time on the patient's 28-day mortality rate. 2. The relationship between storage time and other health problems that the patient may develop (such as heart disease, vascular occlusion, respiratory failure, infection, and organ failure). For this purpose, patients aged 18-75 who were admitted directly from the scene of injury and received large transfusions at Jacksonville Shands Hospital between January 1, 2023, and October 1, 2025, will be included. Data will be obtained from hospital information systems and anesthesia records

Key Dates

Start date

Jan 17, 2026

Status verified

Feb 2026

Primary completion

Jun 1, 2026

Completion

Jun 1, 2026

Study Design

Enrollment

300 participants (estimated)

Arms

• Arm: Group 1
  The study will include patients aged 18-75, with an ISS \>15, who presented directly from the injury scene and received massive transfusion (defined as \>10 packed RBC (PRBC) units in the first 24 hours or ≥3 units in 1 hour) between January 1, 2023, and October 1, 2025. Data will be extracted from hospital information systems and anesthesia records. The storage duration for each transfused unit (from collection to transfusion) will be recorded.

Primary Outcome Measure

28-day Mortality [ Time Frame: At the day of 28 after massive blood transfusion ]

Central Contacts

• ayten saracoglu, prof dr
  +1 (904) 5245932
  [email protected]

Locations (1)

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