Neuroimaging of Adolescent Cannabis Use Treatment

Part of paid clinical trials in Indianapolis, Indiana.

Sponsor
Indiana University
Study ID
NCT07340554
Status
Recruiting
Apply to this trial

Conditions

  • Addiction
  • Addiction, Substance
  • Cannabis Abuse
  • Cannabis Abuse, Episodic Use
  • Cannabis Abuse, in Remission
  • Cannabis Dependence
  • Cannabis Intoxication
  • Cannabis Smoking
  • Cannabis Use
  • Cannabis Use Disorder
  • Cannabis Withdrawal
  • Cannabis-Related Disorder
  • Marijuana
  • Marijuana Abuse
  • Marijuana Dependence
  • Marijuana Smoking
  • Marijuana Use
  • Marijuana Use Disorder
  • Marijuana User
  • Marijuana-Related Disorder
  • Substance Abuse
  • Substance Abuse Drug Chronic
  • Substance Dependence
  • Substance Related Problem
  • Substance Use
  • Substance Use Disorders

Eligibility Criteria

Sex
ALL
Age
14 Years - 17 Years
Healthy Volunteers
Not accepted

Interventions

  • Contingency Management — BEHAVIORAL
    Contingency management is an evidence-based behavioral intervention used to treat substance use disorders, including cannabis use disorder (CUD). Contingency management operates on the principles of instrumental learning, where positive reinforcement is used to encourage desired behaviors, such as abstinence from cannabis. First, specific target behaviors are identified for reinforcement. In CUD, this is often abstinence from cannabis use, verified through regular urine drug screens and self-reports. If the target behavior (i.e., abstaining from cannabis for a specified time period) is achieved, then patients receive tangible rewards immediately after attaining the target behavior. These rewards are often in the form of money, vouchers, or other incentives that are meaningful to the individual. We will examine whether success during contingency management treatment for cannabis use is associated with neural activity during instrumental learning in N=80 adolescents ages 14-17.
  • Elastic Net Regression — DEVICE
    We will apply an elastic net regression model to the neuroimaging data to estimate CUDIT score based on neuroimaging data.

Study Details

This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete drug tests at home. Participants can earn prizes for staying cannabis-free.

Key Dates

Start date
Jun 22, 2026
Status verified
Jun 2026
Primary completion
May 1, 2030
Completion
May 1, 2030

Study Design

Enrollment
80 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Other: Contingency Management and Elastic Net Regression
    All participants will receive Contingency Management treatment for Cannabis Use. An elastic net regression model will be applied to the neuroimaging data for all participants to estimate scores on the CUDIT.

Primary Outcome Measure

Cannabis use frequency [ Time Frame: Screening and Post-Intervention Follow-Up Visit (2-4 weeks after last CM visit) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Indiana University School of MedicineIndianapolisIndiana46202
Joseph Aloi, MD, PhD
[email protected]
317-278-5433
Katherine LeFevre, BS
[email protected]
317-278-5433

Find similar trials in Indianapolis, IN

By condition
Substance use disorder
By specialty
Behavioral healthAddiction medicine
By research site
Indiana University School of Medicine· Indianapolis, IN

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