Transcranial Magnetic Stimulation in Veterans With PTSD

Part of paid clinical trials in White River Junction, Vermont.

Sponsor
White River Junction Veterans Affairs Medical Center
Study ID
NCT07336251
Status
Recruiting
Apply to this trial

Conditions

  • PTSD - Post Traumatic Stress Disorder

Eligibility Criteria

Sex
ALL
Age
19 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Magnetic Stimulation — DEVICE
    10 sessions of low frequency rTMS (1Hz) applied to the right dorsolateral prefrontal cortex.

Study Details

With this research investigators hope to begin to understand how rTMS can improve posttraumatic stress disorder (PTSD) symptoms. TMS improves PTSD through two interrelated mechanisms: change in brain limbic system function and change in systemic inflammatory activation. Participants who decide to join this study, will receive ten rTMS treatments. All participants will undergo a 40-minute rTMS procedure with a member of the study team 10 times over 2-4 weeks. Participants will undergo fMRI scans of the head in order to help researchers better understand potential effects of rTMS on brain activity. In addition, participants will be asked to give two breath and blood samples to look for signs of general inflammation.

Key Dates

Start date
Jan 15, 2026
Status verified
Jan 2026
Primary completion
Jan 31, 2027
Completion
Jan 31, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants receiving open label trial of TMS

Primary Outcome Measure

Frequency and intensity of PTSD symptoms as assessed by the CAPS-5 [ Time Frame: From enrollment to the end of treatment at 3 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
White River Junction VA HospitalWhite River JunctionVermont05001
Bradley Watts, MD, MPH
[email protected]
802-295-9363
Bradley Watts,MD, MPH (PRINCIPAL_INVESTIGATOR)
Brian Shiner MD, MPH (SUB_INVESTIGATOR)

Find similar trials in White River Junction, VT

By research site
White River Junction VA Hospital· White River Junction, VT

Related Studies