A Study of BMS986365 in Combination With Degarelix in People With Prostate Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07335796
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • BMS-986165 — DRUG
    BMS986365 (CC-94676) is an androgen receptor (AR) ligand-directed degrader that was designed to target the AR for degradation in castration-resistant prostate cancer (CRPC)
  • Degarelix — DRUG
    Degarelix is a GnRH antagonist that blocks the action of GnRH on the pituitary and effectively suppresses testosterone production

Study Details

The purpose of this study is to find out whether BMS986365 in combination with degarelix, given before standard surgical treatment (radical prostatectomy), is a safe and effective treatment that causes few or mild side effects for people who have localized high-risk prostate cancer.

Key Dates

Start date
Jan 9, 2026
Status verified
Mar 2026
Primary completion
Jan 9, 2030
Completion
Jan 9, 2030

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with high-risk localized prostate cancer
    Eligible participants with high-risk localized prostate cancer based on one or more of the following: PSA \>20ng/ml, Gleason Score ≥8, or Clinical stage ≥cT3a.

Primary Outcome Measure

Frequency of pathologic complete response/pCR [ Time Frame: 42 months ]

Central Contacts

Locations (6)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Kristine Lacuna, MD
646-888-4321
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Kristine Lacuna, MD
646-888-4321
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)CommackNew York11725
Kristine Lacuna, MD
646-888-4321
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Kristine Lacuna, MD
646-888-4321
Memorial Sloan Kettering Cancer Center (All Protocol Activites)New YorkNew York10065
Kristine Lacuna, MD
646-888-4321
Memorial Sloan Kettering Nassau (Limited Protocol Activites)Rockville CentreNew York11553
Kristine Lacuna, MD
646-888-4321

Find similar trials in Basking Ridge, NJ

By condition
Prostate cancer
By specialty
OncologyProstate oncologyMen's healthUrology
By research site
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activites)· New York, NYMemorial Sloan Kettering Nassau (Limited Protocol Activites)· Rockville Centre, NY

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