First-Time-in-Human Study of GSK5471713 in Adults With mCRPC

Part of paid clinical trials in Grand Rapids, Michigan.

Sponsor
GlaxoSmithKline
Study ID
NCT07332455
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Neoplasms, Prostate

Eligibility Criteria

Sex
MALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • GSK5471713 — DRUG
    GSK5471713 will be administered at different dose levels based on the dose escalation study design

Study Details

This first-time-in-human study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, preliminary clinical activity, and establish the benefit/risk of GSK5471713 given as a monotherapy in mCRPC.

Key Dates

Start date
Feb 10, 2026
Status verified
Apr 2026
Primary completion
Mar 24, 2028
Completion
Mar 26, 2030

Study Design

Enrollment
54 participants (estimated)
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Participants receiving GSK5471713
    Participants will receive GSK5471713, according to their allocated dose level guided by the dose escalation study design.

Primary Outcome Measure

Number of participants with dose limiting toxicities (DLTs) [ Time Frame: 28 days ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
GSK Investigational SiteGrand RapidsMichigan49546
US GSK Clinical Trials Call Center
[email protected]
877-379-3718
EU GSK Clinical Trials Call Centre
[email protected]
+44 (0) 20 8990 4466
Emerson Lim (PRINCIPAL_INVESTIGATOR)
GSK Investigational SitePhiladelphiaPennsylvania19107
US GSK Clinical Trials Call Center
[email protected]
877-379-3718
EU GSK Clinical Trials Call Centre
[email protected]
+44 (0) 20 8990 4466
Kevin Zarrabi (PRINCIPAL_INVESTIGATOR)
GSK Investigational SiteWest Valley CityUtah84119
US GSK Clinical Trials Call Center
[email protected]
877-379-3718
EU GSK Clinical Trials Call Centre
[email protected]
+44 (0) 20 8990 4466
Jose Pacheco (PRINCIPAL_INVESTIGATOR)

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